Misoprostol for all women seeking abortion? : The Lancet [available via free login]: "The second edition of the Royal College of Obstetricians and Gynaecologists guidelines recommended routine use of misoprostol only when the woman was aged younger than 18 years and the gestational age was more than 10 weeks [to soften the cervix]. The Society for Family Planning Guidelines in the USA reported that misoprostol was more effective than laminaria, acted more quickly, and was preferred by women. However, the US guideline did not recommend routine use because of a scarcity of evidence about major complications, and because of the pain and bleeding some women experience before surgery. Instead, use in adolescents in the late first trimester was recommended, and in those in whom cervical dilation is expected to be difficult. The problem with recommendation for such individuals is that prediction of the women for whom surgery will prove difficult is not possible.
"The findings from [this study] make an important contribution to this debate by showing that vaginal misoprostol not only facilitates surgery in healthy women seeking first-trimester abortion, but results in a significantly lower rate of incomplete evacuation."
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