Pregnancy and NSAIDs : OBGYN News: Although NSAIDs are typically contraindicated late in pregnancy, first trimester use has not consistently been associated with increased risks for congenital anomalies in human studies. Animal studies have suggested, in particular, that nonselective NSAIDs such as aspirin, ibuprofen, and naproxen might be associated with increased risks for midline defects, diaphragmatic hernia, and ventricular septal defects. These animal studies have suggested a stronger association with aspirin and weaker effects with nonaspirin NSAIDs (Birth Defects Res. B Dev. Reprod. Toxicol. 2003;68:5-26).
A recent report from the National Birth Defects Prevention Study – an ongoing, large, U.S. multisite, case-control study of major congenital anomalies and maternal exposures – has suggested that specific NSAIDs might be associated with small to moderate increases in risk for several specific congenital anomalies.
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