The Long-Term Effects of In Utero Exposures — The DES Story

The Long-Term Effects of In Utero Exposures — The DES Story — NEJM: For the women who were exposed to DES in utero, it meant being subjected to the trauma of multiple pelvic examinations with colposcopy and repeated biopsies, as well as living with the fear of developing cancer. Small, T-shaped uteri and other uterotubal anomalies that made it impossible to accommodate a growing fetus caused many of these women to have miscarriages — which occurred at twice the rate found among their non–DES-exposed contemporaries.